Titlebook: Synthesis of Therapeutic Oligonucleotides; Satoshi Obika,Mitsuo Sekine Book 2018 Springer Nature Singapore Pte Ltd. 2018 Therapeutic oligo

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Effects of 2′-,-Modifications on RNA Duplex Stabilityecause of their facile synthetic accessibility and large influence on the biological and physical properties of RNA duplexes. This chapter focuses on the effects of chemical modifications on RNA duplex stability. The effects of the 2′-hydroxyl modifications on preorganization of the RNA backbone and

植物茂盛

2′,4′-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moietyd many classes of 2′,4′-bridged nucleic acids have been developed to date. Evaluation of oligonucleotides containing 2′,4′-bridged nucleic acids suggests that, in addition to the bridge size, the number, type, and position of atoms composing the bridge unit affect (i) the binding affinity to target

CHYME

Synthesis and Therapeutic Applications of Oligonucleotides Containing 2′-,,4′-,-Ethylene- and 3′-,,4taining 2′-.,4′-.-ethylene-bridged nucleic acid (ENA) have been synthesized as functional oligonucleotides to further optimize the 2′-.,4′-.-methylene-linkage of bridged nucleic acids (2′,4′-BNA) or locked nucleic acids (LNA). Oligonucleotides containing ENA residues show three notable properties: (

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Development of Triplex Forming Oligonucleotide Including Artificial Nucleoside Analogues for the Antf gene expression and sequencing technologies. In an antiparallel triplex DNA, a purine-rich triplex forming oligonucleotide (TFO) consisting of a dG, dA or T forms two reverse Hoogsteen hydrogen bonds with a GC, AT or AT base pair of the duplex DNA, respectively, with a high selectivity in a sequen

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Chemical Synthesis of Boranophosphate Deoxy-ribonucleotidesare useful as therapeutic agents owing to affinity for complementary RNA, nuclease resistance, RNase H activity, efficient cellular uptake, and potency for gene suppression. Over past two decades, chemists have tried to develop an efficient method for the chemical synthesis of boranophosphate deoxyr

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Springer Nature Singapore Pte Ltd. 2018

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