Titlebook: Synthesis of Therapeutic Oligonucleotides; Satoshi Obika,Mitsuo Sekine Book 2018 Springer Nature Singapore Pte Ltd. 2018 Therapeutic oligo

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Non-protected Synthesis of Oligonucleotides–N bond cleavage using 6-nitro-HOBt is more than 99% in the RNA synthesis without base protection. In this review, we summarize the .-selective phosphorylation in DNA and RNA synthesis without base protection and the synthesis of modified oligonucleotides having alkaline-labile functional groups using these new methods.

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Book 2018tic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of

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Nucleosides and Oligonucleotides Incorporating 2-Thiothymine or 2-Thiouracil Derivatives as Modifiede physicochemical properties of thio-modified bases and the methods for the syntheses of 2-thiouridine and 2-thiothymidine are described. In addition, the solid-phase synthesis of oligonucleotides incorporating these thio-nucleosides is described.

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Site-Specific Modification of Nucleobases in Oligonucleotides, the site-specific modifications focusing on nucleobases within oligonucleotides are summarized. Moreover, as an experimental example of site-specific modification of an oligonucleotide, the preparation of .,.-disubstituted cytosine derivatives using reaction of 4-triazolylpyrimidin-2-one nucleobase with various secondary amines is demonstrated.

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Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-Modiith their complementary nucleic acid within a few seconds of photoirradiation are examined. The details of the synthetic method, properties and the applications for regulating gene expression in cells are discussed.

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and inspire fresh ideas in nucleic acid chemistry.Meets the .This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous