Titlebook: Regulation of Signal Transduction in Human Cell Research; Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie Book 2018 Springer Nature Singapore

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Atsushi Yoshimori,Sei-Ichi Tanumas a series of informative case studiesThis book offers up-to-date information and guidance on the application of metrology in legal proceedings, clarifying the limits of validity of scientific evidence and presenting an illuminating series of case studies in which measurement uncertainty has played

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Using Genetically Engineered Mouse Models to Study Wnt Signaling in Bone Development and Disease, pathway regulates skeletal development and postnatal homeostasis is of great value for human skeletal health. We will review how genetically engineered mouse models (GEMMs) have been and are being used to uncover the mechanisms and etiology of bone diseases in the context of Wnt signaling.

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The HGF/MET Signaling and Therapeutics in Cancer,valuated in clinical trials for the treatment of various cancers. In this chapter, we discuss the role of HGF/MET signaling in cancer development and progression, the strategies for targeting MET signaling, as well as the promises and challenges of MET-targeted therapeutics.

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Using Genetically Engineered Mouse Models to Study Wnt Signaling in Bone Development and Disease,between bone formation (by osteoblasts and osteocytes) and bone resorption (by osteoclasts) controls postnatal bone homeostasis. For the past decade, a vast amount of evidence has shown that Wnt signaling plays a pivotal role in regulating this balance. Therefore, understanding how the Wnt signaling

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,Regulation of EMT by TGF-β Signaling in Cancer Cells,TGF-β can suppress tumorigenesis by inhibiting cell-cycle progression and stimulating apoptosis in the early stages of cancer, suggesting that it acts as a tumor suppressor during cancer initiation. However, TGF-β can also act as a tumor promoter at later stages of cancer progression. TGF-β plays fu