Titlebook: Regulation of Signal Transduction in Human Cell Research; Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie Book 2018 Springer Nature Singapore

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Regulation of Signal Transduction in Human Cell Research

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,Role of the?Receptor-Mediated Signaling Pathways on the?Proliferation and Differentiation of Pluripdent MEK/ERK and PI3K/Akt signaling pathways independent of FGF2..Activation of the Smad signaling pathway by bone morphogenetic proteins (BMPs) and activin/nodal has been shown to promote cardiovascular differentiation of mouse and human ES or iPS cells. In addition, treatment with isoproterenol (a

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,Regulation of microRNA Expression by?Growth Factors in Tumor Development and Progression,ng the translation of growth factor-induced functional molecules. There are a growing number of reports that describe the translational regulation of growth factors, their receptors, and intracellular signaling molecules by miRNAs in various tumors. However, less of the reports describe the regulati

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,Regulation of EMT by TGF-β Signaling in Cancer Cells, are implicated in this process. Among them, TGF-β induces the EMT by propagating intracellular signals and activating transcription factors. This review describes new insights into the molecular mechanisms underlying induction of the EMT by TGF-β in cooperation with signals from growth factors and

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DNA Damage: Cellular Responses, Repair, and Cancer Treatment,owever, have implicated that DNA-PK can regulate DDS through hindrance of ATM-DDS, giving rise to an evolving view in which all three PIKK family members are essential for regulation of DDS, but not its initiation. This chapter presents a discussion of the signaling within human systems induced by D

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Met Activation and Carcinogenesis,tumors mediated by HGF/SF-MET signaling. Such tumors include carcinomas, sarcomas, and lymphomas, demonstrating the breadth of MET signaling as driving force of cancer. In this chapter, we will discuss the role of HGF/SF-MET signaling in carcinogenesis and the animal models used in developing therap

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Pericellular Activation of Peptide Growth Factors by Serine Proteases,receptor tyrosine kinase. There are two mechanisms for HGF activation .: serum activation and cellular activation. Type II transmembrane serine proteases are membrane-anchored proteases that are part of cellular HGF-activating machinery. In the past decade, evidence for the roles of these proteases

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