Titlebook: Regulation of Signal Transduction in Human Cell Research; Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie Book 2018 Springer Nature Singapore

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,The Functional Interplay Between Pro-oncogenic RUNX2 and Hypoxia-Inducible Factor-1α (HIF-1α) Durinnerally O. concentration is less than 2%). The elevated level of hypoxia is tightly associated with genetic instability, tumor progression, drug resistance, and/or poor clinical outcome after treatment, indicating that hypoxia exerts a strong selection pressure for the survival of cancer stem cells

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Met Activation and Carcinogenesis,cer cells, MET is activated upon stimulation by its only ligand, hepatocyte growth factor/scatter factor (HGF/SF), or becomes active due to mutations or amplifications that produce constitutive activation of the MET kinase. The biological consequences of HGF/SF-MET signaling include cell proliferati

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The HGF/MET Signaling and Therapeutics in Cancer,tivates MET to regulate diversified cellular and molecular activities such as proliferation, motility, differentiation, and survival. Aberration of HGF/MET signaling plays a proven role in promoting cancer initiation and malignant progression, providing a strong rationale for targeting the MET signa

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Molecular Designing of Small-Molecule Inhibitors for Apoptosis Regulation,processes has been implicated in a wide variety of diseases, such as cancer, neurodegenerative disorders, and ischemic injury. To date, many kinds of key proteins in apoptotic processes have been identified and targeted for therapeutic strategies. Several effective small molecules have been designed

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https://doi.org/10.1007/978-981-10-7296-3Signal transduction; Carcinogenesis; Cell death; Molecular design; Human cell