| 書目名稱 | Regulation of Cancer Immune Checkpoints | | 副標題 | Molecular and Cellul | | 編輯 | Jie Xu | | 視頻video | http://file.papertrans.cn/826/825656/825656.mp4 | | 概述 | Systematically reviewing the most important findings in regulation of cancer immune checkpoints.Discussing the therapeutic development based on molecular and cellular mechanisms.Helping researchers bu | | 叢書名稱 | Advances in Experimental Medicine and Biology | | 圖書封面 |  | | 描述 | .This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. ..To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune che | | 出版日期 | Book 2020 | | 關鍵詞 | Cancer; Immune checkpoints; Genetic regulation; Transcriptional regulation; Translational regulation; Pos | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-15-3266-5 | | isbn_softcover | 978-981-15-3268-9 | | isbn_ebook | 978-981-15-3266-5Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor |
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