Titlebook: Orexin and Sleep; Molecular, Functiona Takeshi Sakurai,S.R. Pandi-Perumal,Jaime M. Monti Book 2015 Springer International Publishing Switze

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Orexin Induced Modulation of REM Sleep and Its Loss Associated Patho-Physiological Changes Are Medi in health and diseases. Based on the findings/reports from this lab and that of others, we conclude that orexin-induced modulation (loss) of REMS and associated pathophysiological changes are mediated to a large extent at least by influencing the noradrenalin (NA)-ergic neurons in the LC, which possesses REM-OFF neurons.

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History of Orexin Research,iyama et al. in Eur J Neurosci 20:3054–3062, .; Mieda et al. in J Neurosci 24:10493–10501, .; Sakurai et al. in Neuron 46:297–308, .; Yoshida et al. in J Comp Neurol 494:845–861, .; Harris et al. in Nature 437:556–559, .; Narita et al. in J Neurosci 26:398–405, .). Subsequent studies suggested that

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interference

Orexin, Alcohol and Sleep Homeostasis,lamus is involved in spontaneous as well as recovery sleep after prolonged wakefulness. Our second group of experiments suggests that alcohol increases extracellular levels of AD in the orexin-rich perifornical hypothalamus, increased AD activates A1 receptors on orexinergic neurons and inhibits the

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febrile

Symptomatic Narcolepsy or Hypersomnia, with and Without Orexin (Hypocretin) Deficiency, brain tumors, head trauma, and immune-mediated neurological conditions, such as neuromyelitis optica (NMO), and EDS in these cases is sometimes reversible with an improvement of the causative neurological disorder and an improvement of orexin status. It is also noted that some symptomatic EDS cases

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Urologist

Orexin and Circadian Influences in Sleep and Psychiatric Disorders: A Review of Experimental and Coen orexinergic, monoaminergic, circadian oscillators, and sleep-wake neural circuitry. Our main aim is to understand how these physiological systems interact and how alteration in any of these factors can contribute to the behaviours commonly observed in depressive patients. Further, we examine how

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