Titlebook: Lipids in Health and Disease; Peter J. Quinn,Xiaoyuan Wang Book 2008 Springer Science+Business Media B.V. 2008 Activation.Lipid.Metabolism

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Fatty Acid Synthase Activity in Tumor Cellssignificant evolutionary pressure to bypass many of the checks and balances afforded normally. Cancer cells have high energy expenditure from heightened proliferation and metabolism and often show increased lipogenesis. Fatty acid synthase (FASN), the enzyme responsible for catalyzing the ultimate s

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Altered Lipid Metabolism in Brain Injury and Disorders adipose tissue. Atherosclerosis (a risk factor for ischemic stroke) results from accumulation of LDL-derived lipids in the arterial wall. Pro-inflammatory cytokines (TNF-α and IL-1), secretory phospholipase A. IIA and lipoprotein-PLA. are implicated in vascular inflammation. These inflammatory resp

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Lysophospholipid Activation of G Protein-Coupled Receptorsed to the actions of lysophospholipid receptors. The most well characterized lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Documented cellular effects of these lipid mediators include growth-factor-like effects on cells, such as proliferation, survival, migrati

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Phospholipid-Mediated Signaling and Heart Disease cardiac sarcolemmal membrane phospholipid homeostasis. The contribution of the different phospholipases and their related signaling mechanisms to altered function of the diseased myocardium is not completely understood. Resolution of this issue is essential for both the understanding of the pathoph

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Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics bioeffector molecules, which control various aspects of cell growth, proliferation, and anti-cancer therapeutics. Ceramide, the central molecule of sphingolipid metabolism, generally mediates anti-proliferative responses such as inhibition of cell growth, induction of apoptosis, and/or modulation o