| 書目名稱 | Excitotoxicity in Neurological Diseases | | 副標(biāo)題 | New Therapeutic Chal | | 編輯 | Carlo Ferrarese,M. Flint Beal | | 視頻video | http://file.papertrans.cn/319/318415/318415.mp4 | | 圖書封面 |  | | 描述 | It can be reasonably anticipated that, over the next generations, the proportion of elderly people will remarkably increase and, with this, the number ofpersons suffering from acute (e.g. cerebral ischemia) or chronic neurodegenerative disorders. To date, approved drugs only alleviate the symptoms ofthese diseases (for instance, acetylcholinesterase inhibitors in Alzheimer disease and L-dopa and dopamine-agonists in Parkinson disease), while none seems to stop the progression of the degenerative processes underlying them. The development of effective preventive or protective therapies has been impeded by the limitations of our knowledge of the causes and the mechanisms by which neurons die in neurodegenerative disorders. Evidence accumulated in the past 20 years indicated that the major excitatory neurotransmitter glutamate may play a role as neurotoxin in several conditions. In particular, the glutamatergic system dysfunction seems to be an early event working as a common pathway in the pathogenesis ofa large number ofacute and chronic neurological disorders, in strict conjunction with other important mechanisms, such as oxidative stress and energetic failure, and probably trigger | | 出版日期 | Book 2004 | | 關(guān)鍵詞 | Alzheimer; Parkinson; alzheimer‘s disease; brain; brain injury; cerebral ischemia; dementia; glutamate rece | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4419-8959-8 | | isbn_softcover | 978-1-4613-4736-1 | | isbn_ebook | 978-1-4419-8959-8 | | copyright | Springer Science+Business Media New York 2004 |
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