Titlebook: Bone Toxicology; Susan Y. Smith,Aurore Varela,Rana Samadfam Book 2017 Springer International Publishing AG 2017 Bone Pharmacology.Bone Phy

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https://doi.org/10.1007/978-3-031-69773-9from the intracellular cell signaling to the energy metabolism and skeletal mineralization. Kidney, as a primary avenue for the regulating extracellular fluid and electrolyte homeostasis, participates to the maintenance of the continuous bone turnover and mineralization. At the same time, bone is th

pessimism

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Introduction and Considerations in Bone Toxicologyd-points. The ability to use our knowledge of bone biology to ensure study conditions are optimal to detect an effect will be presented. This includes study design considerations and the utility of other models to explore the impact new compounds may have on the skeleton in the development of safe and effective drugs.

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Jean-Pierre Durand,Nicolas Hatzfeldst commonly used species in the study of bone metabolic disorders. Other large animals like dogs, sheep, mini-pigs, or rabbits which are being successfully used to study orthopedic conditions (implant ingrowth, fracture healing, and bone augmentation) have not been addressed in this chapter.

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Living Longer and Healthier at Older Agesnt understanding of the central regulation of bone homeostasis. Herein, we will discuss the contribution of central peptides, and other peptides such as leptin, and semaphorins and involvement of the brain in regulation of bone metabolism.