Titlebook: Bone Toxicology; Susan Y. Smith,Aurore Varela,Rana Samadfam Book 2017 Springer International Publishing AG 2017 Bone Pharmacology.Bone Phy

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The Emergence of Living Lab Methodslating those effects into effects in humans is required, because of the skeletal intermediary organization that only exists in vivo. Bone cells function in vivo within the intermediary organizations of modeling, which controls bone growth and shape changes, and remodeling, which controls bone renewa

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In-Situ and Mixed-Design Interventionse skeleton level and to investigate potential mechanisms. The goal of this chapter is to describe the biochemical markers of bone turnover, consisting of markers of bone formation and bone resorption, considered important when conducting safety assessments in a preclinical setting. The bone formatio

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Arjan van Timmeren,David V. Keysonrties in pharmaceutical testing is critical to understanding the potential effects of that pharmaceutical on bone health and fracture risk. The specific objectives of each study are factors to be considered in deciding which preclinical model and test type(s) to utilize, and it is important to maint

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The Law of Love and the Love of Law,cases, qualitative histopathology has sufficient sensitivity to detect test article-related effects on bone marrow and growth plates in standard toxicity studies, it may lack the sensitivity to detect effects of test articles on key physiological processes in bone tissue such as bone formation, mine

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Living Longer and Healthier at Older Agesfect other tissues, including bone, via secreting factors within the microenvironment to modulate their biological functions. Thus muscle is essential for bone development, modeling, and remodeling. Similar to muscle, bone can also be considered an endocrine organ targeting other tissues such as mus