Titlebook: Biological Reactive Intermediates III; Mechanisms of Action James J. Kocsis,David J. Jollow,Robert Snyder Book 1986 The Editor(s) (if appli

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incontinence

Isomeric Composition of ,-Alkylated Protoporphyrins Produced by Substituted Dihydropyridines , and ,onating their intact 4-alkyl group to one of the pyrrole nitrogens of haem in hepatic cytochrome P-450 (De Matteis et al., 1981; Ortiz de Montellano et al., 1981; Tephly et al., 1981). Because of the asymmetrical arrangement of the two vinyl and propionate side chains in protoporphyrin IX, four stru

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UDP-Glucuronyltransferases and Their Toxicological Significanceraction of the more reactive electrophilic metabolites with critical cellular macromolecules plays a major role in their toxicity (Miller and Miller, 1981). Therefore much interest was given to the control of electrophilic metabolites. However the more stable and more abundant nucleophilic metabolit

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Rat Cytosolic Epoxide Hydrolaseially hydrolyzed by the microsomal form, while .-stilbene oxide is the prefered substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of SpragueDawley (outbred strain) liver cytosolic epoxide hydrolase were observed, varying from 2 to 77 pmol/min x mg

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Multiplicity of Cytochrome P-450 in Morris Hepatomame activities in normal adult liver, from which hepatic tumor was originated (Adamson and Fouts, 1961). Conney et al. (1957) described the remarkable and now widely recognized induction of BP hydroxylase activity in rat liver by the prior administration of BP itself, or 3-methylcholanthrene (MC), or

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Comparison of the Metabolism of Benzene and Its Metabolite Phenol in Rat Liver Microsomese apparent that benzene can also be leukemogenic (Snyder, 1984). Benzene-induced bone marrow depression is caused by one or more metabolites of benzene (Snyder, et al., 1981). Cytochrane P-450 mediates the first step in benzene metabolism (Gonasun et al., 1973). The initial metabolite formed in the

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Age and Sex Differences in Constitutive Forms of Cytochrome P-450 of Rat Liver Microsomesdrug and chemical-treated animals respond to challenge by such agents with an increase in the hepatic microsomal content of cytochrome P-450. It wasn’t long, however, before it was realized that the cytochrome P-450 increase was the result of an induction of different forms of cytochrome P-450..

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Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/b/image/187440.jpg