Titlebook: Antibodies for Treating Cancer; Basics, Development, Melvyn Little Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusi

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https://doi.org/10.1007/978-3-642-92196-4otect him from smallpox. Almost a century later, Louis Pasteur developed vaccinations against diseases such as anthrax and rabies using weakened pathogens. Shortly afterwards, Emil von Behring, Kitasato Shibasaburō, and Paul Ehrlich demonstrated that antitoxins in the serum of horses vaccinated with

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https://doi.org/10.1007/978-3-642-92196-4e regions at the end of the two arms of the Y-shaped antibody, and binding sites for components of the immune system are located in the constant regions of the basal Fc domain. There are five classes of constant regions (A, D, E, G, and M) which determine the particular function of an antibody. The

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https://doi.org/10.1007/978-3-642-92196-4duce tumor cell death by the Fc-mediated effector functions of ADCC (antibody-dependent cellular cytotoxicity), ADCP (antibody-dependent cellular phagocytosis), and CDC (complement-dependent cytotoxicity) or by inhibiting the signaling pathway of growth hormone receptors on the tumor cell surface. T

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https://doi.org/10.1007/978-3-642-92196-4 radionuclides. Most of the toxins from plants and bacteria are enzymes, a single molecule of which can catalyze thousands of reactions. In contrast, non-enzymatic reagents must be potent enough that only a few molecules are able to damage vital structures such as DNA and microtubules. Most of the c

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Einführung in die moderne Kostenrechnung NK and T cells and to tumor-associated antigens (TAAs). Some are based on multivalent full-length antibodies, and others comprise only single chains of antibody variable domains. Indeed, the most successful bispecific antibody to date, a so-called BiTE for treating refractory or relapsed B-cell acu

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