Titlebook: Antibodies for Treating Cancer; Basics, Development, Melvyn Little Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusi

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Life-Saving Antibodies: History of Immunization,otect him from smallpox. Almost a century later, Louis Pasteur developed vaccinations against diseases such as anthrax and rabies using weakened pathogens. Shortly afterwards, Emil von Behring, Kitasato Shibasaburō, and Paul Ehrlich demonstrated that antitoxins in the serum of horses vaccinated with

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Of Mice and Men: Production of Therapeutic Antibodies,ll from the spleen of an immunized mouse with a myeloma tumor cell. The result was an immortal hybridoma cell that produced abundant monoclonal antibodies. For therapeutic use, the immunogenicity of monoclonal antibodies has been reduced either by replacing the murine constant domains with human seq

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Mediation of Tumor Cell Death by Naked Antibodies,duce tumor cell death by the Fc-mediated effector functions of ADCC (antibody-dependent cellular cytotoxicity), ADCP (antibody-dependent cellular phagocytosis), and CDC (complement-dependent cytotoxicity) or by inhibiting the signaling pathway of growth hormone receptors on the tumor cell surface. T

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Antibodies as Magic Bullets, radionuclides. Most of the toxins from plants and bacteria are enzymes, a single molecule of which can catalyze thousands of reactions. In contrast, non-enzymatic reagents must be potent enough that only a few molecules are able to damage vital structures such as DNA and microtubules. Most of the c

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Novel Modular Antibodies, two β-pleated sheets stabilized by a disulfide bridge. The variable domains at the end of the Fab arms containing the hypervariable antigen-binding regions can be used for constructing “mini-antibodies” which retain the binding properties of the original antibody but without its effector functions.

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