Titlebook: Antibodies for Treating Cancer; Basics, Development, Melvyn Little Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusi

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Die Kosten- und Leistungsstellenrechnung,nce of understanding the biology and mechanisms of cellular interactions within the tumor microenvironment (TME). A majority of antibodies in development for treating cancer are directed against immune checkpoints (ICs). They are being evaluated in more than 3000 clinical trials as first or second l

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978-3-030-72601-0The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl

FAWN

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Book 2021by inhibition of negative immune regulation. Many of the antibodies that are now being brought to market target precisely these immune checkpoint modulators...The book addresses a broad readership, ranging from professionals and experts in the field to residents and medical students..

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https://doi.org/10.1007/978-3-642-92196-4id tumors. They have opened a window for treating cancers such as malignant melanomas that were previously resistant to therapy. Tumors that are particularly amenable to treatment with IC inhibitors are characterized by a high mutation rate and a significant number of tumor-infiltrating lymphocytes