Titlebook: Alternatives for Dermal Toxicity Testing; Chantra Eskes,Erwin van Vliet,Howard I. Maibach Book 2017 Springer International Publishing AG 2

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The In Vitro Membrane Barrier Test Corrositex, for Skin Corrosionositex assigns chemicals both to UN packing groups I, II, III and Non-corrosive, and to GHS corrosive subcategories 1A, 1B, 1C (accepting “not Catergory 1” results also). The degree of corrosivity potential of a chemical is predicted by measuring its penetration time through calibrated biobarriers into a chemical detection system.

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The EpiDerm? Skin Irritation Test (EpiDerm? SIT)on centers and regulators, several in vitro test methods have been developed, validated and regulatory adopted as potential replacements of the rabbit skin irritation test..This chapter describes in details the skin irritation test (SIT) based on the use of the in vitro reconstructed human epidermis

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An , Skin Irritation Test Using the SkinEthic? Reconstructed Human Epidermal (RHE) Modeltation properties of chemicals (OECD TG 439). The SkinEthic? RHE skin irritation test method has been shown to be robust and transferable. The reproducibility and predictivity of the SkinEthic? RHE assay have been evaluated in validation studies organized with three laboratories, and with a set of 2

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The epiCS? Skin Irritation Test (SIT) Methodduction, these cells differentiate in a multilayered epidermis that serves as a model for human . epidermis. For the epiCS. SIT method, the tissues are exposed to test substances for 20 min followed by a 42 h post-incubation period. Subsequently, the relative viability of the tissues is determined b

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The EpiSkin? Human Epidermis Model for In Vitro Skin Corrosion of Test Chemicalsod has been shown to be robust, transferable, and reproducible in validation studies organised with three laboratories. The overall accuracy of the EpiSkin? test method in distinguishing between corrosive and non-corrosive chemicals was 92.4% with a large set of 113 chemicals through a systematic .