Titlebook: Alternatives for Dermal Toxicity Testing; Chantra Eskes,Erwin van Vliet,Howard I. Maibach Book 2017 Springer International Publishing AG 2

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https://doi.org/10.1007/978-3-8349-9707-4on centers and regulators, several in vitro test methods have been developed, validated and regulatory adopted as potential replacements of the rabbit skin irritation test..This chapter describes in details the skin irritation test (SIT) based on the use of the in vitro reconstructed human epidermis

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https://doi.org/10.1007/978-3-8349-9707-4consists of normal human epidermal keratinocytes whose biological origin is neonatal foreskin. The several validation studies of the . skin irritation test method using LabCyte EPI-MODEL24 (LabCyte EPI-MODEL24 SIT) were conducted at three laboratories to assess both intra- and interlaboratory reprod

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https://doi.org/10.1007/978-3-8349-9707-4duction, these cells differentiate in a multilayered epidermis that serves as a model for human . epidermis. For the epiCS. SIT method, the tissues are exposed to test substances for 20 min followed by a 42 h post-incubation period. Subsequently, the relative viability of the tissues is determined b

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https://doi.org/10.1007/978-3-8349-9707-4ve been validated and adopted in the regulation as early as 2000 in the European Union and in 2004 at the OECD level. Current internationally agreed approaches recommend the use of Integrated Approach for Testing and Assessment (IATA) that allow to replace or minimize to the extent possible the use

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https://doi.org/10.1007/978-3-8349-9707-4od has been shown to be robust, transferable, and reproducible in validation studies organised with three laboratories. The overall accuracy of the EpiSkin? test method in distinguishing between corrosive and non-corrosive chemicals was 92.4% with a large set of 113 chemicals through a systematic .