Titlebook: Store-Operated Ca2? Entry (SOCE) Pathways; Emerging Signaling C Klaus Groschner,Wolfgang F. Graier,Christoph Roman Book 2017Latest edition

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Dora Bodnar,Woo Young Chung,Dongki Yang,Jeong Hee Hong,Archana Jha,Shmuel Muallem

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Hayley Dingsdale,Emmanuel Okeke,Lee Haynes,Gyorgy Lur,Alexei V. Tepikin

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Brochure

高談闊論

The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complexhlight structures of human Orai1 N-terminal and C-terminal domains in complex with calmodulin and human STIM1, respectively. Ultimately, the accessible structural data are discussed in terms of potential mechanisms of action and cohesiveness with functional observations.

REIGN

STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC ComplexesM1, both channel types function at the ER/PM (plasma membrane) junctions. This chapter describes the properties and regulation of the channels by STIM1, with emphasis how and when TRPC channels function as STIM1-dependent and STIM1-independent modes and their unique Ca.-dependent physiological functions that are not shared with the Orai channels.

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STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex the participation of several other components, many of which remain unidentified to this date. Here we review several of the proteins identified as constituents of the so-called store-operated calcium influx complex (SOCIC) and discuss their role in modulating this complex phenomenon.

隼鷹

Introductional Ca. increase), it is vital for the normal functioning of multiple types of cells and tissues, and when misregulated it induces important pathological processes. The reader hopefully agree that such an important “tail” is more appropriate for a kangaroo than for a Chihuahua and that it has awesome wagging capacity.

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CLOT

The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modificationsnvolved in a plethora of cellular responses, the cross-talk between reactive oxygen species (ROS) and Ca. is critical for homeostatic control. Identification of calcium regulatory protein targets of thiol redox modifications is needed to understand their role in biology and disease.