Titlebook: Sigma Receptors: Their Role in Disease and as Therapeutic Targets; Sylvia B. Smith,Tsung-Ping Su Book 2017 Springer International Publishi

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Sigma-1 Receptor in Motoneuron Disease,e neuroprotection and neurite elongation through activation of protein kinase C on motoneurons in vitro and in vivo after ventral root avulsion. Remarkably, treatment of SOD1 mice, the most usual animal model of ALS, with Sigma-1R agonists resulted in significantly enhanced motoneuron function and p

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Peeking into Sigma-1 Receptor Functions Through the Retina,d by in vitro and in vivo experiments. Most recently, studies suggest that S1R may also protect retinal neurons via its activities in Müller glia and microglia. The S1R functions in the retina may be attributed to a reduction of excitotoxicity, oxidative stress, ER stress response, or inflammation.