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Titlebook: Sigma Receptors: Their Role in Disease and as Therapeutic Targets; Sylvia B. Smith,Tsung-Ping Su Book 2017 Springer International Publishi

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書(shū)目名稱Sigma Receptors: Their Role in Disease and as Therapeutic Targets
編輯Sylvia B. Smith,Tsung-Ping Su
視頻videohttp://file.papertrans.cn/868/867038/867038.mp4
概述Very few books about Sigma receptors, yet the field regarding Sigma receptors has exploded.A comprehensive treatise on this unique protein.Of significant relevance to very severe diseases (blindness,
叢書(shū)名稱Advances in Experimental Medicine and Biology
圖書(shū)封面Titlebook: Sigma Receptors: Their Role in Disease and as Therapeutic Targets; Sylvia B. Smith,Tsung-Ping Su Book 2017 Springer International Publishi
描述.Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable?potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types.? It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease,?Huntington’s disease,?pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors.? Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein..
出版日期Book 2017
關(guān)鍵詞Drug Target; Molecular Chaperone; Neurodegeneration; Neuroprotection; Sigma 1 Receptor; Receptors
版次1
doihttps://doi.org/10.1007/978-3-319-50174-1
isbn_softcover978-3-319-84335-3
isbn_ebook978-3-319-50174-1Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightSpringer International Publishing AG (outside the USA) 2017
The information of publication is updating

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,The Evolution of the Sigma-2 (σ,) Receptor from Obscure Binding Site to , Therapeutic Target,o binding studies over 25 years ago, the molecular identity of this protein is currently not unambiguously known, and the results from recent attempts to identify the σ. receptor through protein purification and mass spectral analysis have been the subject of debate in the literature. However, there
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Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain,ies and reduce their unwanted effects. Current preclinical evidence supports the modulatory role of sigma-1 receptors (σ.R) in nociception, mainly based on the pain-attenuated phenotype of σ.R knockout mice and on the antinociceptive effect exerted by σ.R antagonists on pains of different etiologies
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Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Ampldiseases. Accumulating evidence indicates that sigma-1 ligands can either directly or indirectly modulate multiple neurodegenerative processes, including excitotoxicity, calcium dysregulation, mitochondrial and endoplasmic reticulum dysfunction, inflammation, and astrogliosis. In addition, sigma-1 l
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