Titlebook: Sigma Receptors: Their Role in Disease and as Therapeutic Targets; Sylvia B. Smith,Tsung-Ping Su Book 2017 Springer International Publishi

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Book 2017 treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors.? Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein..

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Structural Perspectives on Sigma-1 Receptor Function,each protomer binds a single ligand molecule at the center of its carboxy-terminal domain. These results offer detailed molecular views of receptor structure, oligomerization, and ligand recognition, providing a framework for the next era of sigma-1 research.

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Sigma Receptors and Substance Use Disorders, including cocaine, methamphetamine, and alcohol. The present chapter will review the current scientific knowledge on the role of the Sigma Receptor system in the effects of drugs and alcohol, and proposes that this receptor system may represent a novel therapeutic target for the treatment of substance use disorders and associated neurotoxicity.

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0065-2598 f significant relevance to very severe diseases (blindness, .Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable?potential as therapeutic targets. In this text, n

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Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mic B (Akt) activities in hippocampus. Therefore, we discuss the fundamental roles of Sig-1R, CaMKII/CaMKIV and protein kinase B (Akt) signaling in amelioration of depressive-like behaviors following Sig-1R stimulation.