Titlebook: Selenium; Its Molecular Biolog Dolph L. Hatfield,Marla J. Berry,Vadim N. Gladyshe Book 20062nd edition Springer-Verlag US 2006 AIDS.Diabete

Diverticulitis

Evolution of selenocysteine decoding and the key role of selenophosphate synthetase in the pathway o greatly contributed to shape our view on the evolution of selenium utilization in nature. Current evidence is consistent with the idea that Sec decoding is a late addition to the genetic code and it evolved once, before the separation of archaeal, bacterial and eukaryal domains. Many organisms have

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SECIS RNAs and K-turn binding proteins. A survey of evolutionary conserved RNA and protein motifs is mandatory to allow the ribosome to readthrough the UGA selenocysteine codon. The SECIS RNA possesses a well-defined secondary structure. Four consecutive non-Watson-Crick base pairs, with a central tandem of sheared G.A/A.G base pairs, constitute the functional motif of the SECIS RNA which is re

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SECIS binding proteins and eukaryotic selenoprotein synthesisncorporate Sec rather than terminate protein synthesis involves at least two RNA-binding proteins that interact specifically with a conserved motif within the 3’ untranslated region (3’ UTR) of the selenoprotein mRNA. The structures, functions, and interactions of these two proteins, SECIS Binding P