Titlebook: Regulatory Mechanisms of Intracellular Membrane Transport; Sirkka Ker?nen,Jussi J?ntti Book 20041st edition Springer-Verlag Berlin Heidelb

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1610-2096 plementary material: .This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular n

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Molecular mechanisms in clathrin-mediated membrane budding,network (TGN) where they function in protein transport from the secretory pathway to the endosomal/lysosomal system. It has been long thought that clathrin and the clathrin adaptors 1 (AP-1) and 2 (AP-2) could define a minimal machinery for the formation of CCVs and the selection of cargo. However,

Cougar

Regulating membrane curvature,esis, and creation of the high-curvature vesicles and tubules that mediate cargo transport along the endo- and exocytic pathways. Yet membrane bilayers are stabilized against deformations by a powerful hydrophobic effect. Moreover, the various membrane-bound organelles of a cell are composed of diff

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Functions of Rab GTPases in organelle biogenesis,d hydrolysis by Rab are harnessed to recruit and activate specific effector proteins that regulate vesicle tethering and fusion, cargo sorting, and cytoskeleton-dependent organelle transport. We review recent progress in understanding how Rab GTPases are regulated and how they regulate membrane traf

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