Titlebook: Regulatory Mechanisms of Intracellular Membrane Transport; Sirkka Ker?nen,Jussi J?ntti Book 20041st edition Springer-Verlag Berlin Heidelb

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1610-2096 plementary material: .This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular n

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Molecular mechanisms in clathrin-mediated membrane budding,network (TGN) where they function in protein transport from the secretory pathway to the endosomal/lysosomal system. It has been long thought that clathrin and the clathrin adaptors 1 (AP-1) and 2 (AP-2) could define a minimal machinery for the formation of CCVs and the selection of cargo. However,

Cougar

Regulating membrane curvature,esis, and creation of the high-curvature vesicles and tubules that mediate cargo transport along the endo- and exocytic pathways. Yet membrane bilayers are stabilized against deformations by a powerful hydrophobic effect. Moreover, the various membrane-bound organelles of a cell are composed of diff

浸軟

Functions of Rab GTPases in organelle biogenesis,d hydrolysis by Rab are harnessed to recruit and activate specific effector proteins that regulate vesicle tethering and fusion, cargo sorting, and cytoskeleton-dependent organelle transport. We review recent progress in understanding how Rab GTPases are regulated and how they regulate membrane traf

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