Titlebook: RNA Technologies in Cardiovascular Medicine and Research; Volker A. Erdmann,Wolfgang Poller,Jan Barciszewski Book 2008 Springer-Verlag Ber

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Noncoding RNAs in Human Diseasession of genetic information. Discoveries of new classes of RNA without protein coding potential and large scale cDNA sequencing projects demonstrated that, contrary to the original view, the cellular functions and the processes associated with growth and development of organisms do not depend solely

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Nucleic Acid Aptamers for Cardiovascular Therapeuticsin target with high specificity and affinity. Aptamers can be generated in a controlled and entirely in vitro process known as SELEX. Advances in aptamer technology have made possible the application of this therapeutic modality to many therapeutic areas including cardiovascular indications. To that

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NFκB Decoy Oligodeoxynucleotide-Based Therapy in Cardiovascular Diseasesthe regulation of powerful transcriptional factors which could be mainly involved in the process of atherosclerosis, myocardial infarction, and vascular remodeling, etc. The transcription factor nuclear factor-kappa B (NF-κB) plays a pivotal role in the coordinated transactivation of cytokine and ad

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Antisense Therapy for Restenosis Following Percutaneous Coronary Interventionsg responses that can lead to vessel obstruction or restenosis following injury..Recent studies have focused on the use of antisense compounds to prevent recurrent vessel obstruction or restenosis following PTCA. Some antisense compounds can inhibit the cell cycle response to injury in the G-1 by blo

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Toxic RNA in Pathogenesis of Human Neuromuscular Disordersof these diseases, such as myotonic dystrophy, fragile X-associated tremor/ataxia syndrome, spinocerebellar ataxias 8, 10, 12 and Huntington’s disease-like 2, are caused by an increased number of tri-, tetra- or pentanucleotide repeats in noncoding regions of the mutated genes. An RNA gain-of-functi

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RNA Technologies in Cardiovascular Medicine and Research978-3-540-78709-9

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