Titlebook: RNA Technologies in Cardiovascular Medicine and Research; Volker A. Erdmann,Wolfgang Poller,Jan Barciszewski Book 2008 Springer-Verlag Ber

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Explosive

miRNAs and Their Emerging Role in Cardiac Hypertrophyf targeted messenger RNAs (mRNAs). More than one-third of human protein-coding mRNAs are predicted as being regulated by miRNAs, which have been implicated in processes as diverse as cancer and muscle biology. Now, recent studies demonstrate that the expression profiles of many miRNAs change during

Expostulate

MicroRNAs and the Control of Heart Pathophysiologynt class of gene regulatory molecules in multicellular organisms, and are being implicated in an increasing number of biological processes. Many miRNAs are expressed in a tissue-specific manner during development and take part in the regulation of cell-lineage decisions and morphogenesis. Moreover,

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MicroRNA Systems Biologytrast, RNAs have been thought as molecules which are only transferring genetic information for protein production. Recently, microRNAs (miRNAs) have emerged as another layer of gene regulation. They regulate many key biological processes, including cell growth, death, development and differentiation

Lethargic

Targeting Viral Heart Disease by RNA Interferenced an important cause for VHD in both populations. VHD may lead to dilated cardiomyopathy and heart failure which can ultimately require heart transplantation. However, no specific treatment modality is so far available. We and others have shown that coxsackieviral replication and cytotoxicity can be

Arthritis

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奇思怪想

Cardiac Delivery of Nucleic Acids by Transcriptional and Transductional Targeting of Adeno-Associateficiency of cardiac transfer. Efficient and sustained cardiac delivery in large animal models and finally clinical trials requires transfer of vectorized shRNA with suitable application systems. Packaging shRNA constructs in targeted adeno-associated viral (AAV) vectors may be versatile for systemic

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Characterization of Hammerhead Ribozymes Potentially Suitable for the Treatment of Hyper-Proliferatirhead ribozymes were the first type of nucleic acid based drugs to be extensively studied and predicted to be of potential practical utility. These are catalytic RNA molecules capable of inducing the site-specific cleavage of a phosphodiester bond within an RNA molecule. Thus, they can be used to re

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