Titlebook: RAMPs; William S. Spielman,Narayanan Parameswaran Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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RAMPs and CGRP Receptors,-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor. It seems likely that Y66, F93, H97 and F101, amongst other residues, form a binding site for CLR. These cluster together on the same fac

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Understanding RAMPs Through Genetically Engineered Mouse Models,ve diverse spatiotemporal expression patterns. Biochemical and pharmacological studies in cultured cells have shown that RAMPs can modulate several aspects of G receptor (GPCR) signaling, including receptor trafficking, ligand binding affinity, second messenger signaling and receptor desensitization

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RAMPs as Drug Targets, can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, severa

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Ramp Like Proteins,nsporting Protein) and REEP (Receptor Expression Enhancing Protein) family of proteins were first identified as partners for ORs, promoting cell-surface expression and leading to functional responses in heterologous cell systems. Like RAMPs, the RTP and REEP proteins appear to partner with GPCRs to

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Regulation of RAMP Expression in Diseases,led receptors; calcitonin receptor and the calcitonin-receptor like receptor (CLR). To date, three members of RAMP family (RAMP-1, -2, -3) have been identified. The co-expression of RAMP-1 with CLR constitutes the calcitonin gene related peptide receptor whereas the association of the RAMP-2 or RAMP

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ectrochemistry and adjacent sciences and technologies.Suppli.The “Electrochemical Dictionary” provides up-to-date, broad and authoritative coverage of the specific terms most used in electrochemistry and its related fields, including relevant areas of physics and engineering. This modern compendium

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Narayanan Parameswaran,William S. Spielmanectrochemistry and adjacent sciences and technologies.Suppli.The “Electrochemical Dictionary” provides up-to-date, broad and authoritative coverage of the specific terms most used in electrochemistry and its related fields, including relevant areas of physics and engineering. This modern compendium

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James Barwell,Denise Wootten,John Simms,Debbie L. Hay,David R. Poynerectrochemistry and adjacent sciences and technologies.Suppli.The “Electrochemical Dictionary” provides up-to-date, broad and authoritative coverage of the specific terms most used in electrochemistry and its related fields, including relevant areas of physics and engineering. This modern compendium