Titlebook: RAMPs; William S. Spielman,Narayanan Parameswaran Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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tanding of the electrochemical terms they encounter. More than 300 figures and illustrations elaborate the textual definitions. The “Electrochemical Dictionary” also contains biographical entries of people who have substantially contributed to electrochemistry..978-3-642-09404-0978-3-540-74598-3

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Book 2012life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years..

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Book 2012volved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of

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Regulation of GPCR Trafficking by RAMPs,ting to suggest that the RAMP isoform in complex with CLR may play a role in determining the intracellular trafficking and fate of ligand-stimulated receptor complexes. In this chapter, we will review the current literature on mechanisms of regulating receptor trafficking and roles that have been demonstrated for RAMPs in this regulation.

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Ramp Like Proteins,ce expression and leading to functional responses in heterologous cell systems. Like RAMPs, the RTP and REEP proteins appear to partner with GPCRs to promote cell-surface expression. Unlike RAMPs, they do not appear to alter the pharmacology of the partner receptor.

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Introduction to Ramps, G-protein coupled receptors (GPCRs) to the plasma membrane. Since its discovery in 1998, several pivotal advances have been made in understanding the function of this family of proteins. This chapter provides a basic introduction to RAMPs as well as details on the various chapters in this book.