Titlebook: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery; Gus R. Rosania,Greg M. Thurber Book 2021 Springer Science+Bus

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Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery978-1-0716-1250-7Series ISSN 1557-2153 Series E-ISSN 1940-6053

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https://doi.org/10.1007/978-1-0716-1250-7Pharmacokinetics; Drug development; Small molecule pharmacology; Biologics; Macromolecule transport; Nano

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Book 2021sition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologi

Glossy

Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytesns, and technical considerations for experimental design, and provide protocols for measuring intracellular unbound drug concentrations and subcellular distribution of xenobiotics in sandwich-cultured hepatocytes and in isolated perfused livers. Additionally, some emerging tools and technologies will be explored briefly.

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Quantitative Drug Target Imaging Using Paired-Agent Principlesxtract estimates of drug target concentration from paired-agent data under a number of conditions: topical and systemic delivery, and imaging of intravascular, extracellular, and intracellular drug targets.

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Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence ofonally, for the purpose of high-throughput screening of drug candidates during the earliest stages of drug development, transport assays are performed with commercially available, in vitro cell cultures as experimental models. Based on theoretical, physiologically based pharmacokinetics principles,

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