Titlebook: Oral Antidiabetics; Jochen Kuhlmann,Walter Puls Book 1996 Springer-Verlag Berlin Heidelberg 1996 Antidiabetics.Biguanides.Diabetes.Diabete

champaign

爆炸

多節(jié)

mortuary

Ligneous

Toxicology of Biguanidese, phenylethylbiguanide (phenformin), was given marketing approval in the United States in 1957. Due to the serious side effects, however, the compound was withdrawn from the market in the United States and the major European countries about 20 years later. Similar problems occurred with .-butylbigu

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Clinical Pharmacology of Biguanides983; . 1992). Repeated reports of phenformin-associated lactic acidosis led to the withdrawal of this biguanide in the United States in 1977 and in most other countries. Buformin shared the same fate, but metformin escaped withdrawal, even if the use became more restricted. At the same time the Univ

ARY

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overhaul

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