Titlebook: Oral Antidiabetics; Jochen Kuhlmann,Walter Puls Book 1996 Springer-Verlag Berlin Heidelberg 1996 Antidiabetics.Biguanides.Diabetes.Diabete

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Sulfonylureas: Physico-chemical Properties, Analytical Methods of Determination and Bioavailabilitytic drugs include acetohexamide, acetylcarbutamide, carboxytolbutamide, carbutamide, chlorpropamide, glibenclamide, glibornuride, gliclazide, glimepiride, glipizide, gliquidone, glisoxepide, metahexamide, tolazamide and tolbutamide. The structural formulas of some of the important antidiabetic agents are given in Fig. 1.

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令人悲傷

Clinical Pharmacology of Sulfonylureasion of insulin secretion. Sulfonylureas bind to receptor-like structures on the B cell, which may be closely linked to or be part of the potassium channels (. et al. 1987; . et al. 1988; . et al. 1990). The binding capacity of different sulfonylureas reflects their ability to stimulate insulin secretion.

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Chemistry and Structure-Activity Relationships of Glucosidase Inhibitorse rational design of a lead compound, when the biochemical mechanism and the structure of the enzyme are well known. In the late 1960s, when we started to look for such potent and selective inhibitors, we had to choose the random screening approach, relying mainly on testing of extracts of the culture broths of microorganisms.

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0171-2004 -threatening disease. This attitude needs to be changed because the complications asso- ciated with the adult form of diabetes affect almost every organ system. The high morbidity and mortality of non-insulin-dependent diabetes mellitus (NIDDM) suggest that current treatment strategies are unsatisfa

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