Titlebook: Oncolytic Viruses; Methods and Protocol David H. Kirn,Ta-Chiang Liu,Stephen H. Thorne Book 2012 Springer Science+Business Media, LLC 2012 N

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Imaging Luciferase-Expressing Viruses,defective and replication-competent adenoviruses in mouse and hamster models of oncolysis and virus pharmacology. Although these methods are simple, the process of obtaining accurate luciferase imaging data has many caveats that are discussed.

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Arbitrary

Adenoviral Gene Expression and Replication in Human Tumor Explant Models,re conditions, primary human tumor tissue remained viable for up to 48 h, enabling evaluation of viral mutants in tissue with intact morphology. This assay may have great utility to investigate novel viral mutants and to identify treatment sensitive cancers by assessing specific oncolytic mutants in individual cases.

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Propagation, Purification, and In Vivo Testing of Oncolytic Vesicular Stomatitis Virus Strains,ibodies targeting mainly the VSV-G surface glycoprotein arise within 3–5 days following the initial dose. This should be considered for strategies aiming at increasing the effectiveness of VSV through delivery of additional doses of virus or aiming to prolong VSV replication in vivo.

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Next-Generation Oncolytic Vaccinia Vectors,array of virulence genes whose deletion may target different properties of the cancer cell, and a large cloning capacity allowing for insertion of multiple transgenes, the possibilities for further development of novel and next-generation oncolytic vectors are multitude.

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Book 2012search remains vital for the translation of research in this field, its success depends on breakthroughs in clinical studies. .Oncolytic Viruses: Methods and Protocols. describes the construction and purification of capsid-modified adenoviruses as well as oncolytic adenoviruses, presents protocols f

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