Titlebook: Oncolytic Viruses; Methods and Protocol David H. Kirn,Ta-Chiang Liu,Stephen H. Thorne Book 2012 Springer Science+Business Media, LLC 2012 N

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In Vivo Positron Emission Tomography Imaging Using the Sodium Iodide Symporter as a Reporter Gene,re efficient reagents. Although optical imaging can be used to gain this information in rodent models, imaging with radioactive isotopes presents the advantage of being directly applicable to humans, and preclinical imaging data can provide a basis for the design of clinical protocols. In this chapt

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Targeting Brain Tumor Stem Cells with Oncolytic Adenoviruses,ot for tumor initiation and resistance to therapies. Thus, it is imperative to develop new therapies that can eradicate this subpopulation to improve the prognosis of patients with brain tumors. Our group previously reported the antiglioma effect of the tumor-selective oncolytic adenovirus Delta-24-

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Oncolytic Measles Virus Retargeting by Ligand Display,pment of novel therapeutic approaches. Virotherapy approaches have considerable potential, and among them measles virus (MV) vaccine strains have emerged as a promising oncolytic platform. Retargeted MV strains deriving from the Edmonston vaccine lineage (MV-Edm) have shown comparable antitumor effi

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neuron

Analysis of Three Properties of Newcastle Disease Virus for Fighting Cancer: Tumor-Selective Replicpears to be associated with three properties of the virus:.NDV may use several mechanisms to exert its tumor-killing action: direct cytotoxicity against cancer cells but also nonspecific as well as active-specific antitumor immune responses from the host organism. All the methods described here allo

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Evaluation of Innate Immune Signaling Pathways in Transformed Cells,exhibit the ability to preferentially replicate in and kill cancer cells plausibly due to defects in innate immune signaling or translation regulation that are acquired during cellular transformation. Here, we review concepts and assays that describe how to analyze signaling pathways that govern the