Titlebook: Nucleosides and Nucleotides as Antitumor and Antiviral Agents; Chung K. Chu,David C. Baker Book 1993 Springer Science+Business Media New Y

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,A Synthesis of 2’-Fluoro- and 3’-Fluoro-Substituted Purine Nucleosides , a Direct Approach,There are many examples of purine nucleosides fluorinated in the 2′- and 3′ -positions of the sugar moiety (Figure 1) that are making an impact in chemistry, biochemistry, and drug development.

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,Modified Oligoribonucleotides: Synthesis and Preliminary Evaluation of α-RNA,ribonucleotides have been described. One of the reasons for this situation may be related to the fact that RNA synthesis is more sophisticated than that of DNA , due to the presence of the 2′-OH function, which necessitates the use of an added protection that is compatible with all the other protective groups.

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