Titlebook: Nucleosides and Nucleotides as Antitumor and Antiviral Agents; Chung K. Chu,David C. Baker Book 1993 Springer Science+Business Media New Y

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CROW

興奮過度

Interregnum

航海太平洋

Lithiation Chemistry of Uridine Derivatives: Access to a New Anti-HIV-1 Lead,erstanding of the reaction mechanism.. Since a number of functional groups have been recognized to have ortho-directing ability,. and since lithiated species usually react with a wide range of electrophiles under mild conditions, lithiation strategy has become an efficient alternative to classical electrophilic aromatic substitution.

BARGE

Capitulate

emotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease

Ingredient

Neuralgia

,Allenols Derived from Nucleic Acid Bases — A New Class of Anti-HIV Agents: Chemistry and Biologicalles of two structurally different classes of nucleoside analogues. Acyclovir (1a) belongs to a series of open-chain compounds derived by cleavage of at least one C-C bond or deletion of one or more carbon atoms of the sugar ring, whereas AZT (3b) comprises an intact furanose moiety.

LUCY

,Adenosine-Derived 5′-α-Halo Thioether, Sulfoxide, Sulfone, and (5′-Halo)Methylene Analogues. Inhibidation/elimination processes.. It had been demonstrated that 4′,5′-didehydro-5′-deoxyadenosine [9-(5-deoxy-?-D-erythro-pent-4-enofuranosyl)adenine, 6] was accepted as an alternative substrate by AdoHcy hydrolase and converted into Ado and AdoHcy.. Therefore, we also targeted 5′-halo analogues of 6 a