Titlebook: Novel Approaches to Selective Treatments of Human Solid Tumors; Laboratory and Clini Youcef M. Rustum Book 1993 The Editor(s) (if applicabl

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Enhanced Cytotoxicity of 5-Fluorouracil Combined with [6RS]Leucovorin and Recombinant Human Interferof intracellular 5,10-methylenetetrahydrofolate (CH.-H.PteGlu.).. Whereas the concentration of this reduced folate may not be rate limiting for thymidylate synthesis ., it may be suboptimal to allow maximal interaction between the FUra metabolite, 5-fluorodeoxyuridylate (FdUMP), and thymidylate synt

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Biochemical Modulation of 5-Fluorouracil by Pala: Mechanism of Actionchemical differences between cancer and normal cells are quantitative rather than qualitative. Consequently, anticancer agents have a narrow therapeutic index and, therefore, chemotherapy is frequently toxic to the patient as well as to the tumor.

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Fluorouracil and Leucovorin in Advanced Breast Cancerced breast cancer. In previously-untreated patients, the combination generates objective responses in over one third of women with a very modest and acceptable toxicity profile. It is also clear that the addition of mitoxantrone or cisplatin to 5-FU and leucovorin produces very effective regimens, t

Cholecystokinin

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Shousong Cao,Zhanggeng Zhang,Patrick J. Creaven,Youcef M. Rustumithic archaeologists and human paleontologists have failed to address the origins of a phenomenon that is both absolutely central to the human way of life and unique to our species. ..In all species of mammals, there are codes (rules, concepts, values, etc.) that govern behavior. Among humans, and o

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Godefridus J. Peters,Giovanni Codacci-Pisanelli,Clasina L. van der Wilt,Jan A. M. van Laar,Kees Smidithic archaeologists and human paleontologists have failed to address the origins of a phenomenon that is both absolutely central to the human way of life and unique to our species. ..In all species of mammals, there are codes (rules, concepts, values, etc.) that govern behavior. Among humans, and o

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