Titlebook: Novel Approaches to Selective Treatments of Human Solid Tumors; Laboratory and Clini Youcef M. Rustum Book 1993 The Editor(s) (if applicabl

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978-1-4613-6060-5The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines

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0065-2598 Overview: 978-1-4613-6060-5978-1-4615-2488-5Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Biochemical Modulation of 5-Fluorouracil by Pala: Mechanism of Actionchemical differences between cancer and normal cells are quantitative rather than qualitative. Consequently, anticancer agents have a narrow therapeutic index and, therefore, chemotherapy is frequently toxic to the patient as well as to the tumor.

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Cellular Interactions Between the Natural and Unnatural Isomers of 5-Formyltetrahydrofolatelu). All reduced folates have an S chirality at the 6 carbon of the tetrahydropterine ring and the natural and unnatural isomers of 5-formyltetrahydro-folate are designated respectively as (6S)- and ...H.H.PteGlu.. After being used for many years as a rescue agent following high doses of the antifol