Titlebook: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins; Ulf Grawunder,Stefan Barth Book 2017 Springer International Publishing A

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Stable and Homogeneous Drug Conjugation by Sequential Bis-Alkylation at Disulphide Bonds Using Bis- disulphide bond in antibodies and antibody fragments. We have demonstrated that the bis-sulphone-derived conjugates retain antigen-binding, are stable in serum and exhibit potent and antigen-selective cell killing in both in vitro and in vivo cancer models. Disulphide re-bridging conjugation is a g

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Calicheamicin Antibody-Drug Conjugates for Liquid and Solid Tumor Indications,evelopment, including the ADC, inotuzumab ozogamicin, targeting CD22-positive, liquid tumors including NHL and ALL, and the CD33-targeting gemtuzumab ozogamicin, targeting AML..The recent expansion of the utility of calicheamicin conjugates to solid tumors may have a broader impact on ADC developmen

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Enzyme-Based Strategies to Generate Site-Specifically Conjugated Antibody Drug Conjugates,C brentuximab vedotin (Adcetris.) and the anti-HER-2 ADC trastuzumab-emtansine (Kadcyla.), are approved for cancer therapy. In fact, Kadcyla. is only approved as a second-line therapy in breast cancer due to a limited clinical benefit in comparison to standard therapy as a first-line therapy. There

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