Titlebook: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins; Ulf Grawunder,Stefan Barth Book 2017 Springer International Publishing A

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JADED

Milestones in Drug Therapyhttp://image.papertrans.cn/n/image/666181.jpg

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https://doi.org/10.1007/978-3-319-46877-8Antibody based cancer therapy; Antibody drug conjugates (ADC); Immunotoxin development; Pyrrolobenzodia

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Epidural-Space

Chemical Assembly of Antibody-Drug Conjugates, over 60 are in clinical trials. Although many ADCs involve non-specific drug attachment via lysine and cysteine residues, the desire to produce homogeneous ADCs has led to the development of several site-specific chemical assembly strategies. The first site-specific ADCs are just beginning to enter

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Stable and Homogeneous Drug Conjugation by Sequential Bis-Alkylation at Disulphide Bonds Using Bis-ion in ADC development is that much effort and time is needed to fully optimise the combination of antibody, linker and drug. New linker strategies are required to ensure that more homogeneous and stable ADCs can be produced with more predictable in vivo behaviour without the need for extensive re-o

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