Titlebook: Neurotransmitter Transporters; Harald H. Sitte,Michael Freissmuth Book 2006 Springer-Verlag Berlin Heidelberg 2006 Associated Proteins.Gen

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Zn2+ Modulation of Neurotransmitter Transporters,d to be an important tool for studying the molecular function of these proteins. We also interpret the current available data on Zn.-binding sites in the context of the recently published crystal structures. Moreover, we review how the identification of endogenous Zn.-binding sites has indirectly su

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Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concent with transporters, largely because the techniques that have been successful in discovering transporter agonists and antagonists do not yield detailed kinetic information. Mechanistic data are for the most part restricted to global parameters, such as . . and . ., measured from large populations of

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,The Importance of Company: Na+ and Cl? Influence Substrate Interaction with SLC6 Transporters and Ovity. Coordination of ions can involve a number of residues, and portions of the substrate and coupling ion binding sites can be distal in space in the tertiary structure of the transporter, with other portions that are close in space thought to be crucial for the coupling process. The reactivity wi