Titlebook: Neurotransmitter Transporters; Harald H. Sitte,Michael Freissmuth Book 2006 Springer-Verlag Berlin Heidelberg 2006 Associated Proteins.Gen

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Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport nsport very many compounds. However, our knowledge about actual substrates is rather limited. 1-Methyl-4-phenylpyridinium (MPP.) is an excellent substrate for all three carriers, with clearances typically in the range of 20-50 μl min. mg protein.. The secondbest general substrate is tyramine with a

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savage

The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action,rs, share several characteristics with classical ligand-gated ion channels. In addition, substrates for transport promote redistribution of DAT away from the plasma membrane, while transport inhibitors such as cocaine disrupt this process. In addition, presynaptic autoreceptors for dopamine have bee

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Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Plthe coatomer coat proteins that are needed for ER-to-Golgi trafficking. In this review, we will start with a brief description on transporter oligomerization that underlies ER-to-Golgi trafficking, followed by an introduction to ER-to-Golgi trafficking of neurotransmitter transporters. Finally, we w

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Acute Regulation of Sodium-Dependent Glutamate Transporters: A Focus on Constitutive and Regulated stead, glutamate is cleared by a family of Na.-dependent transport systems that are found on glial processes that sheath the synapse and found on the pre- and postsynaptic elements of neurons. These transporters ensure crisp excitatory transmission by maintaining synaptic concentrations below those

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Regulation and Dysregulation of Glutamate Transporters,sms of a number of neurodegenerative diseases. A dysfunction of the glutamate transporter is thought to contribute to cell death during excitotoxicity. Therefore, efforts have been made to understand the regulation of glutamate transporter function. Transporter activity can be regulated in different

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Human Genetics and Pharmacology of Neurotransmitter Transporters,bute to individual differences in behavior and neuropsychiatric disorders. This chapter summarizes current knowledge of transporters with a focus on genomic variations, expression variations, pharmacology of protein variants, and known association with human diseases.

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