Titlebook: Neurophenotypes; Advancing Psychiatry Vinoth Jagaroo,Susan L. Santangelo Book 2016 Springer Science+Business Media LLC 2016 Behavioral gene

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Introduction and Structure of the Volumec of the volume—neural and cognitive markers. The emergence of “omics” disciplines is described—where large or complex data sets are deciphered with bioinformatics methods in a systems biology framework. The developments of phenomics in the context of genome-to-phenome mapping, connectomics in neuro

Celiac-Plexus

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陳舊

Cognitive Phenotypes and Endophenotypes: Concepts and Criteria rely on heterogeneous clusters of symptoms that are not closely associated with direct drug targets, discovery of new treatments almost always occurs by chance. Conventional diagnostic phenotypes are marked by significant heterogeneity and overlap, calling into question the biological validity of t

無(wú)關(guān)緊要

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Limitations of the EP Concept in an Idealized Gene–Phene Frameworkmative (see Chaps.?. and . in this volume). Until such flexible perspectives are more widely adopted, the assumptions inherent in the gene-centered endophenotype (EP) concept remain a theoretical basis for tempering the CP construct. Numerous critiques of the EP construct have been written (e.g., Fl

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Fear Conditioning and Extinctiongnitive, behavioral, and neurobiological mechanisms underlying memory formation. After providing an overview and definitions of fear conditioning and extinction, this chapter discusses the cognitive and neural mechanisms of fear conditioning and extinction, including cognitive, behavioral, and devel

清澈

Antecedent

Reward Dependence and Reward Deficiencyhese behaviors and the stimuli that elicit them is an extended cortical–subcortical network in which dopamine (DA) acts as the major neurotransmitter for reward and reinforcement. Genes that control dopamine-related synthesis, vesicular storage, metabolism, receptor formation, and catabolism have va