Titlebook: Neurophenotypes; Advancing Psychiatry Vinoth Jagaroo,Susan L. Santangelo Book 2016 Springer Science+Business Media LLC 2016 Behavioral gene

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Appraising Circuit-Centered Neurophenotypestenuation of the notion of a circuit neurophenotype in the behavioral neurosciences, and this is given some depth of coverage in this chapter. However, the chapter does not dismiss the utility of the concept of circuit neurophenotypes. It concludes with a discussion of the kinds of additional inform

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Fear Conditioning and Extinctionow well do they represent the putative genetic basis for anxiety. The evidence for reliability, heritability, and association with anxiety disorders is reviewed along with a discussion of the issues of co-segregation and state-independency.

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Neural Markers of Errors as Endophenotypes in Neuropsychiatric Disordersf errors meet several important criteria as endophenotypes including heritability, established neuroanatomical and neurochemical substrates, association with neuropsychiatric disorders, presence in syndromally unaffected family members, and evidence of genetic mediation. Understanding the mechanisms