Titlebook: Neoplastic Transformation in Human Cell Culture; Mechanisms of Carcin Johng S. Rhim,Anatoly Dritschilo Book 1991 Springer Science+Business

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Jonathan A. Rhim,Jonathan Vogel,Chang-Min Kim,Gilbert Jay,Johng S. Rhim

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Studies of Mutagen-Activated Genes which Confer Anchorage-Independence: the , Gene as a Modelvely growing tumors (9), and, consistent with this, the anchorage-independent cell clones senesce at passage levels similar to non-anchorage-independent cell clones (6). When neo-plastic transformation is viewed in the context of a multiple-step transition from normal to neoplastic cell (10), mutage

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Polyamine Metabolism in Human Epidermal Keratinocytes Transformed with AD12-SV40, HPV16-DNA and K-, llels the proliferation response. In addition to the possibility of rapidly changing their rate of polyamine synthesis, cells are equipped with an effective pathway for degradation of spermidine and spermine. The first, and rate-limiting, step in this degradation is an acetylation of the polyamines,

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Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expressionvation and immediate early gene induction may represent initial common events which are then followed by rare presumably mutational processes which result in neoplastic transformation. The potential importance of this finding is demonstrated by the recent report that PKC inhibitors partially suppres

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Detection of Transforming Genes from Radiation Transformed Human Epidermal Keratinocytes by a Tumoricyte system led us to determine the potential of X-rays as a carcinogenic agent in human epithelial cells and to characterize the molecular events involved in the development of a radiation-induced malignancy.

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An Inherited P53 Point Mutation in a Cancer Prone Family with Li-Fraumeni Syndromeave differently as compared to the mutant p53 previously detected in transformed cells. Given the inherited nature of this p53 mutation, the demonstrated role of p53 in tumorigenesis and the location of mutation in a region of the gene known to be critical for its function, it appears that we have i

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Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfectedrmation of squamous carcinomas when cells were innoculated in nude mice. Thus, HPV-immortalized cervical cells are an appropriate model for studying the importance of specific environmental or host factors in cervical malignancy.

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