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Titlebook: Neoplastic Transformation in Human Cell Culture; Mechanisms of Carcin Johng S. Rhim,Anatoly Dritschilo Book 1991 Springer Science+Business

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發(fā)表于 2025-3-21 18:54:41 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Neoplastic Transformation in Human Cell Culture
副標(biāo)題Mechanisms of Carcin
編輯Johng S. Rhim,Anatoly Dritschilo
視頻videohttp://file.papertrans.cn/663/662646/662646.mp4
叢書名稱Experimental Biology and Medicine
圖書封面Titlebook: Neoplastic Transformation in Human Cell Culture; Mechanisms of Carcin Johng S. Rhim,Anatoly Dritschilo Book 1991 Springer Science+Business
描述The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi- mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the- art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver- sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans- formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 spea
出版日期Book 1991
關(guān)鍵詞Activation; DNA; aging; cancer; cancer research; carcinogenesis; carcinoma; cell; cell culture; mutation; onco
版次1
doihttps://doi.org/10.1007/978-1-4612-0411-4
isbn_softcover978-1-4612-6750-8
isbn_ebook978-1-4612-0411-4
copyrightSpringer Science+Business Media New York 1991
The information of publication is updating

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Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging the information gained from animal studies will extend to humans. However, a fundamental difference must exist between human and rodents in terms of neoplastic development because cancers generally arise in rodents after a few years whereas the same cancers require decades in humans. For example, t
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Transformation of Human Diploid Fibroblasts by Radiation and Oncogenestransformation .. Whether the progeny of this cell will eventually give rise to an invasive, malignant tumor depends upon a number of host and tissue factors. The malignant transformation of cells . is also a complex, multi-step process by which normal cells acquire the various phenotypic characteri
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