Titlebook: Natural Products; Drug Discovery and T Lixin Zhang,Arnold L. Demain Book 2005 Humana Press 2005 cancer.drug.drug delivery.drug discovery.re

小口啜飲

Friction

Implicit

Improving Drug Discovery From Microorganisms provides a model for improving the efficiency of natural-product discovery. The application of advanced genomics and bioinformatics technologies is now poised to revolutionize natural-product discovery and lead a renaissance of interest in microorganisms as a source of bioactive compounds for drug development.

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indigenous

ANIM

New Natural-Product Diversity From Marine Actinomycetes high rate of novel secondary metabolite discovery, including molecules with potent biological activity. Given the encouraging results from preliminary studies of these newly described marine bacteria, it seems clear that marine actinomycetes represent an important future resource for small-molecule drug discovery.

ABASH

Book 2005ormance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms.

公司

Natural Products and Drug Discoveryondary metabolites helped to double our life span, reduced pain and suffering, and revolutionized medicine. The increased development of resistance to older antibacterial, antifungal, and antitumor drugs has been challenged by (.) newly discovered antibiotics (e.g., candins, epothilones); (.) new se

Medicaid

Integrated Approaches for Discovering Novel Drugs From Microbial Natural Productsinical specificity. However, only a small percentage of known microbial secondary metabolites have been tested as natural-product drugs. Natural-product programs need to become more efficient, starting with the collection of environmental samples, selection of strains, metabolic expression, genetic

cajole

Automated Analyses of HPLC Profiles of Microbial Extractsay from natural products in favor of synthetic approaches. However, the abundance of synthetic compounds with similar functional groups and, therefore, limited chemical diversity has renewed interest in nature as a good resource for finding new ideas to be applied to the design of the next generatio