Titlebook: Mechanistic Models of Asymmetric Reductions; Atsuyoshi Ohno,Satoshi Ushida Book 1986 Springer-Verlag Berlin Heidelberg 1986 Coenzym.amino

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衰老

Working-Memory

Asymmetric Reduction by Model Compounds of NAD(P)H,rogen is substituted by a simple substituent, such as 1-propyl-1,4-dihydronicotinamide (PNAH), 1-benzyl-1,4-dihydronicotinamide (BNAH), or Hantzsch ester (HEH), can be considered as a model compound for NAD(P)H.

extemporaneous

大約冬季

Asymmetric Reduction in a Chiral Reaction Field,ihydropyridine moiety. The active site of the enzyme is surrounded by amino acid residues that form a chiral environment so as to achieve the asymmetric reduction of substrates. One of the attempts to mimic the system conveniently is to introduce one chirality into a 1,4-dihydropyridine derivative.

DEMN

Polar Effect Exerted by Other Asymmetric Reactions,rivative. Especially, this is true when the magnesium ion is present in the reduction system. The idea is different from the traditional one which insists that steric bulk is the most important factor in determining the steric course of a reaction. All of them, the Prelog model (Prelog 1953), Cram m

BALE

Stereochemistry of Flavin-Dependent Reactions,. One is flavin mononucleotide (FMN), and the other is flavin adenine dinucleotide (FAD). Oxidized form of FAD is shown here. The structures of FMN and riboflavin (vitamin B.), which are constituents of FAD, are also depicted. Both FAD and FMN involve the 7,8-dimethylisoalloxazine ring which acts as

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Introduction,al reactions increases by a great many investigations in biochemistry, organic chemists are encouraged to mimic such excellent reactions for their own systems. These attempts have been aimed not only at developing a new type of reducing agent with excellent properties for organic synthesis, but also

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Asymmetric Reduction in a Chiral Reaction Field,selective reduction should be achieved. One of the most effective NAD(P)H model compounds of this type is that which has a macrocyclic moiety in the molecule. The compound was designed with the intention of binding a substrate or a metal ion at the macrocyclic moiety.