Titlebook: Mass Spectrometry in Biology & Medicine; A. L. Burlingame,Steven A. Carr,Michael A. Baldwin Book 2000 Springer Science+Business Media New

Immunoglobulin

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Deciphering Functionally Important Multiprotein Complexes by Mass Spectrometry,n the enzymatic activity can be reproduced in an . experiment and the chemical mechanisms of the reaction can be elucidated in detail [1]. However if the enzyme is involved in regulation of a cellular activity it seldom acts by itself. Enzymatic activity is controlled and targeted to specific substr

FACT

Investigation of Apoptosis-Involved Processes by Mass Spectrometric Identification of the Apoptosishe programmed cell death plays a major role in development, homeostasis and immune response in multicellular organisms and controls lymphocyte growth and selection, this research area has not attracted great interest in the past for several reasons. First, the efficient disposal of apoptotic cells b

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,IR-MALDI — Softer Ionization in MALDI-MS for Studies of Labile Macromolecules,ectrospray ionization (ESI) and MALDI are the two major soft ionization techniques for the intact analysis of macromolecules by mass spectrometry. While MALDI-MS provides inherently fast data acquisition and spectra facile for data analysis, ESI is considered to be the softer of the two techniques a

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Identification of , Phosphorylation Sites with Mass Spectrometry,n modulate enzyme activity, alter affinity to other proteins, and transmit signals through kinase cascades that often are branched and interactive. To understand the molecular basis of these regulatory mechanisms, it is necessary to determine the sites that are phosphorylated .. Mass spectrometry is

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,Glycosylation of Proteins — A Major Challenge in Mass Spectrometry and Proteomics,t most proteins within the nucleus and cytoplasm are also dynamically modified by the addition and removal of saccharides [1]. Indeed, in eukaryotes most polypeptides are glycosylated. Extracellular protein-bound glycans are generally complex and large, whereas cytosolic and nuclear glycans are ofte

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Brain-Waves