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Titlebook: Lupus; Molecular and Cellul Gary M. Kammer,George C. Tsokos Book 1999 Springer Science+Business Media New York 1999 Antigen.apoptosis.autoi

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發(fā)表于 2025-3-21 16:21:32 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Lupus
副標題Molecular and Cellul
編輯Gary M. Kammer,George C. Tsokos
視頻videohttp://file.papertrans.cn/590/589127/589127.mp4
叢書名稱Contemporary Immunology
圖書封面Titlebook: Lupus; Molecular and Cellul Gary M. Kammer,George C. Tsokos Book 1999 Springer Science+Business Media New York 1999 Antigen.apoptosis.autoi
描述Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells.Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.
出版日期Book 1999
關(guān)鍵詞Antigen; apoptosis; autoimmunity; bacteria; cytokine; genetics; inflammation; lymphocytes; macrophages; patho
版次1
doihttps://doi.org/10.1007/978-1-59259-703-1
isbn_softcover978-1-4757-5686-9
isbn_ebook978-1-59259-703-1
copyrightSpringer Science+Business Media New York 1999
The information of publication is updating

書目名稱Lupus影響因子(影響力)




書目名稱Lupus影響因子(影響力)學科排名




書目名稱Lupus網(wǎng)絡公開度




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Genetics of Systemic Lupus Erythematosus,the promise of enhanced insights to be gained from the study of spontaneous and induced autoimmune disease in animals. However, this enthusiasm is tempered by the fact that nearly two decades after particular major histocompatibility complex (MHC) alleles were found to be associated with SLE, we sti
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Lessons from Knockout and Transgenic Lupus-Prone Mice,umbers of T cells unable to undergo Fas-induced cell death after activation. Nevertheless, such animals with known genetic alterations provide substantially increased insight into the lupus immune system by allowing an examination of disease manifestations in the setting of known immune deficiencies
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B Cells in Systemic Lupus Erythematosus,ven though questions always arise whether the derived conclusions can be transferred unmodified to human disease. This chapter focuses on the contribution of B cells to the pathogenesis of human SLE, and makes reference to the murine models of lupus to clarify our understanding of the autoimmune B c
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T Cell Autoimmunity in Lupus,identical to those important in experimental models of lupus autoimmunity. For example, autoimmune-prone mice depleted of either B or T lymphocytes fail to exhibit the typical immunologic or pathologic outcomes of this disease .. However, these mice also fail to respond to pathogens or conventional
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Natural Killer Cells and CD8+ T Cells in the Downregulation of Antibody Production in Healthy Subjeroduction have been described. The identity and characterization of antigen nonspecific regulatory cells has been a principal interest of our group. Whereas Stohl has focused his attention on the role of cytolytic T cells in SLE (. Chapter 18), we have contemplated how antigen nonspecific suppressor
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