Titlebook: Lung Inflammation in Health and Disease, Volume I; Yong-Xiao Wang Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusi

砍伐

indifferent

Scott A. Barman,Zsuzsanna Bordan,Robert Batori,Stephen Haigh,David J. R. Fulton

Uncultured

BULLY

Galectin-3 Promotes ROS, Inflammation, and Vascular Fibrosis in Pulmonary Arterial Hypertension,ammation, and fibrosis, but its role in PAH is poorly understood. Herein, we summarize the recent literature on the role of Gal-3 in the development of PAH and provide experimental evidence supporting the ability of Gal-3 to influence reactive oxygen species (ROS) production, NOX enzyme expression,

archaeology

Medley

Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension,ay fail to provide clinically significant improvements. Correspondingly, network biology could further the development of novel therapeutics which target clusters of “disease genes” so that a disease phenotype can be more robustly addressed. In this chapter, we seek to explain the theory behind netw

潛移默化

Pulmonary Inflammation and KRAS Mutation in Lung Cancer,ersistent potentiation for KRAS-associated lung tumorigenesis. We will discuss in this chapter regarding the studies of KRAS gene mutations in specimens from lung cancer patients and in animal models for investigating the role of inflammation in increasing the risk of lung tumorigenesis driven prima

圓錐體

MicroRNA Targets for Asthma Therapy,employ microRNA mimics and antagonists designed for use in vivo. Chemically modified oligonucleotides have enhanced stability in blood, increased cell permeability, and optimized target specificity. Delivery to lung tissue limits clinical applications, but it is a tractable problem. Future studies n

EVADE

大量殺死

Role of Airway Smooth Muscle in Inflammation Related to Asthma and COPD,in the contractile phenotype involved in airflow limitation, airway hyperresponsiveness, and β.-adrenergic desensitization but also to alteration of the synthetic/proliferative phenotype involved in airway remodeling. These Ca. signal pathways are also associated with synergistic effects due to allo